By Dr. Sam Speron, Board-Certified Plastic Surgeon
GLP-1 medications, such as semaglutide (found in Ozempic® and Wegovy®) and tirzepatide (found in Mounjaro®), are advanced treatments that aid in weight loss by:
These medications work harmoniously with your body's natural processes, offering a supportive approach to weight management.
Request For Information →GLP-1 medications may be suitable for individuals who:
Have a BMI of 30 or higher
Have a BMI of 27 or higher with a related health condition like PCOS or insulin resistance
Have struggled with traditional diet and exercise programs
Are under physician care, such as our clinic's supervision
Microdosing of GLP-1 medications like semaglutide (Ozempic®, Wegovy®) and tirzepatide (Mounjaro®, Zepbound®) is becoming a common off-label strategy to personalize weight loss treatment. This approach involves using doses smaller than those officially FDA-approved, allowing patients and prescribers to better manage side effects, improve tolerability, prevent overtreatment, and reduce medication costs.
For patients using multi-dose pens, microdosing often involves adjusting the number of “clicks” when dialing the pen — a method that requires attention to device concentration and proper technique to avoid dosing errors or infections.
While microdosing offers flexibility, it also comes with risks:
Storage and Stability Concerns: Extended use beyond recommended timeframes may affect medication safety.
Limited Evidence: While small clinical trials show that lower doses can still promote significant weight loss with fewer side effects, more research is needed on real-world microdosing practices.
Shared Decision-Making is Key: Every patient responds differently. Personalized care means evaluating progress every 4 weeks and adjusting doses based on individual results — not following a rigid escalation plan.
At Chicago Concierge Weight Loss Clinic, we prioritize patient-centered, physician-guided care. Microdosing may be considered on a case-by-case basis after a full discussion of potential risks and benefits.
Important: Microdosing is not FDA-approved. Always consult your medical provider before adjusting your medication regimen.
If you’re interested in learning more about individualized GLP-1 dosing, or if you’d like to explore a personalized, concierge approach to weight loss, contact our team today!
Our next success story could be yours
The information provided by Chicago Concierge Weight Loss Clinic and Chicago Center for Anti-Aging, Inc. is for general wellness and educational purposes only. We are not your primary care physician and do not replace the need for a personal medical doctor. Our services are not intended to diagnose, treat, or manage medical conditions outside the scope of our programs. You should continue to see and maintain a relationship with your primary care physician or appropriate medical specialist for ongoing medical care and management of all health conditions.
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